Berlin-based cyber-security experts Karsten Nohl and Jakob Lell demonstrated how malicious code on
hardware connected via USB could "hijack" a PC, and gather private data.
The duo said there is no practical way to defend against the vulnerability.
The body responsible for the USB standard said manufacturers could build in extra security.
It is not uncommon for USB sticks to be used as a way of getting viruses and other malicious code onto target
Most famously, the Stuxnet attack on Iranian nuclear centrifuges was believed to have been caused by an
infected USB stick.
However, this latest research demonstrated a new level of threat - where a USB device that appears completely empty can still contain malware, even when formatted.
The vulnerability can be used to hide attacks in any kind of USB-connected device - such as a smartphone.
"It may not be the end of the world today," Mr Nohl told journalists, "but it will affect us, a little bit, every day,
for the next 10 years".
'Chip' exploited USB -
which stands for Universal Serial Bus - has become the standard method of connecting devices to computers due to its small size, speed and ability to charge devices.
USB memory sticks quickly replaced floppy disks as a simple way to share large files between two computers.
The connector is popular due to the fact that it makes it easy to plug in and install a wide variety of devices.
Devices that use USB contain a small chip that "tells" the computer exactly what it is, be it a phone, tablet or
any other piece of hardware.
It is this function that has been exposed by the threat.
In one demo, shown off at the Black Hat hackers conference in Las Vegas, a standard USB drive was inserted into a normal computer.
Malicious code implanted on the stick tricked the machine into thinking a keyboard had been plugged in.
After just a few moments, the "keyboard" began typing in commands - and instructed the computer to download a malicious program from the internet.
Another demo, shown in detail to the BBC, involved a Samsung smartphone. When plugged in to charge, the phone would trick the computer into thinking it was in fact a network card. It meant when the user accessed the internet, their browsing was secretly hijacked.
Mr Nohl demonstrated to the BBC how they were able to create a fake copy of PayPal's website, and steal user log-in details as a result.
Unlike other similar attacks, where simply looking at the web address can give away a scam website, there were no visible clues that a user was under threat.
The same demo could have been carried out on any website, Mr Nohl stressed.
Mike McLaughlin, a security researcher from First Base Technologies, said the threat should be taken seriously.
"USB is ubiquitous across all devices," he told the BBC.
"It comes down to the same old saying - don't plug things in that you don't trust.
"Any business should always have policies in place regarding USB devices and USB drives. Businesses should stop using them if needed."
The group responsible for the USB standard, the USB Working Party, refused to comment on the seriousness of the flaw. But in more general terms, it said: "The USB specifications support additional capabilities for security, but original equipment manufacturers (OEMs) decide whether or not to implement these capabilities in their products.
"Greater capabilities of any product likely results in higher prices, and consumers choose on a daily basis
what they are willing to pay to receive certain benefits.
"If consumer demand for USB products with additional capabilities for security grows, we would expect OEMs to meet that demand."
Mr Nohl said the only protection he could advise was to simply be ultra-cautious when allowing USB devices to be connected to your machines.
"Our approach to using USB will have to change," he told the BBC.