The initial planned launch of the spacecraft on Monday was delayed due to a yacht in the surrounding danger zone.
The rocket was due to carry nearly 5,000lb (2,200kgs) of supplies to six astronauts aboard the International Space Station (ISS).
There was also equipment for experiments to examine the growth of pea shoots in orbit and how the body's immune system reacts to space travel.
"We will understand what happened, hopefully soon, and we'll get things back on track," said Frank Culbertson, executive vice-president of Orbital Sciences.
"We've all seen this happen in our business before, and we've all seen the teams recover from this, and we will do the same."
He added it was possible his company's staff had triggered the rocket's destruct mechanism after the launch went wrong, but that he was not certain.
But he urged locals to avoid the crash area as the rocket had been carrying "hazardous materials".
"Certainly don't go souvenir hunting along the beach," he said.
The operation, which by chance was on the same day as the Antares launch, was planned long before Wednesday's accident, officials said.
"These are actually modified Russian-built power units that were originally developed for the ill-fated Soviet Moon rocket, the N-1.
"They have been refurbished to modern standards, but one blew up in ground testing earlier this year."